The 2-Minute Rule for Indazole Products
Substitution at R3 with a halogen or alkoxy group (74f–74i) triggered a slight boost in cellular potency With all the halide analogs (74g–h) displaying greatest the potency within the group. Additional optimization resulted in the invention of 74i–j, with 74k as the most Energetic compound inside the series (pIC50 = six.77) with great LLE val